Objective To investigate the application value of combined scanning of 3.0T MRI multiple sequences in evaluating the severity of craniocerebral injury. Methods The clinical data of 80 patients with craniocerebral injury admitted to our hospital from February 2014 to March 2016 were collected. All patients were examined with 3.0T MRI multiple sequences. MRI features in patients with different degrees of craniocerebral injury were compared, and the value of each sequence in the detection of craniocerebral injury was analyzed. Results The number of bleeding foci in patients with craniocerebral injury detected by ESWAN was more than other sequences, followed by FLAIR sequence. Lesions in temporal and occipital parietal lobes and frontal lobe were relatively more. The lesions in the mild group detected by MRI were less than that the moderate group and the severe group (P<0.05), and the detected lesions in the moderate group were fewer than the severe group (P<0.05). The volume of hemorrhage in different parts of the mild group was smaller than that in the moderate group and the severe group (P<0.05), and the volume of hemorrhage in the moderate group was smaller than that in the severe group (P<0.05). Conclusion The combined scanning of 3.0T MRI multiple sequences can fully display intracranial lesions in patients with craniocerebral injury, and the display rate of ESWAN is the highest. With the exacerbation of craniocerebral injury, hemorrhage increases and the volume increases.