Objective To investigate the MR imaging features of infant cerebral cortical laminar necrosis. Methods We retrospectively analyzed the MR images of 29 infant CLN patients, who were examined in our MR department from May 2012 to January 2016. We studied the MR imaging characteristics and after-effect signs. Results 8 cases were diagnosed suppurative meningitis, 7 cases were diagnosed ACI, 5 cases were diagnosed viral encephalitis, 5 cases were diagnosed cerebral trauma, 4 cases were diagnosed HIE and hypoglycemic encephalopathy. CLN could be found in 19.3 days after the illnesses attack. CLN appeared gyriform high signal in T1WI and FLAIR. At the acute phase,the CLN range in T1WI was same with in DWI. In DWI, The cortex lesions appeared diffusionlimited at the acute phase,there were no high signals in the T1WI or FLAIR. At this moment, the range of high signals in DWI less than in T1WI. 19 cases were followedup 1-28 months, the CLN were existed and accompanied with encephalomalacia and/or encephalatrophy. Conclusion The CLN of infant was mostly happened to suppurative meningitis, ACI, viral encephalitis, cerebral trauma, HIE and hypoglycemic encephalopathy. Typical imaging features of CLN is gyriform high signal in T1WI and FLAIR. DWI could early forecast the position and the range of CLN. The CLN could existed in almost 2 years. The prognosis is not good.