Objective To comparative analysis of CT scan and dynamic enhanced CT examination isolation, the clinical value of pulmonary nodules. Methods According to the benign and malignant of nodules, sixty patients confirmed by pathology of SPN patients were divided into two groups, using Siemens 16 layers spiral CT scanner body for patients with dynamic enhanced scan different times, comparison between groups of multiphase dynamic enhanced parameters, CT signs, and the results are statistically analyzed, using ROC curve analysis of the the sensitivity and specificity in the diagnosis of malignant SPN. Results There was a significant difference in the CT value, the clearance value at 20min, the clearance rate and the linear slope at the 120s after the dynamic enhancement of benign and malignant pulmonary nodules. The difference between benign and malignant SPN in type 2 and type 3 TDC was statistically significant. The remaining types of TDC were not statistically significant. The area under the ROC curve (AUC) was 0.796 with a sensitivity of 61.7% and a specificity of 86.5%. AUC of ROC curve was 0.964 (P<0.01), and the sensitivity and specificity were 98.9% and 88.7%, respectively. The CT value of AUC Was 0.975 (P<0.01), with a sensitivity of 99.3% and a specificity of 90.5%. Conclusion Compared with CT scan, dynamic contrast-enhanced CT scan can simultaneously observe the morphological features and enhancement indexes of SPN, and the combination of dynamic enhancement parameters and morphological features can effectively improve the diagnostic efficiency of SPN.