Objective To investigate the diffusion weighted magnetic resonance imaging (DWI) technique and magnetic resonance imaging, fluid attenuated inversion recovery (fluid attenuated inversion recovery, FLAIR) in the analysis of acute cerebral infarction in the clinical value of early diagnosis. Methods From January 2014 to August 2015 in our hospital, 86 patients with acute cerebral infarction underwent magnetic resonance DWI and FLAIR scan, among them, 16 cases belonged to the super acute phase (<6h), 32 cases belonged to the acute stage (6~24h), and 38 cases belonged to subacute phase (24-72h), compared and analyze the range, boundary and contrast of lesions in DWI and FLAIR images. Results (1) the range of DWI and FLAIR sequences was larger than that of conventional T1WI and T2WI, and the contrast of DWI and FLAIR sequences was better than that of conventional T1WI and T2WI. Compared with FLAIR, DWI showed clearer lesions. (2)In DWI, the diffuse whole direction is clearer than the single direction display, and the higher the b value of DWI, the clearer the display of the lesion. Conclusion DWI technique is the most sensitive to acute cerebral infarction, and it can be used to determine the hyperacute and acute cerebral infarction by combining FLAIR technique. The DWI sequence has a clear advantage in the diagnosis of acute cerebral infarction, early release of 24 hours, especially in the 6 hours of hyperacute cerebral infarction, for patients with timely treatment and reduce sequelae, has a very important clinical significance.