Objective To investigate and analyze the value of MRI in the diagnosis of inflammatory demyelinating pseudotumor of the central nervous system. Methods A total of 50 cases of central nervous system inflammatory demyelinating pseudotumor diagnosed in our hospital during February 2015-2017 April were selected by the digital table method as the objects, to explore the MRI manifestations and diagnostic value of MRI diagnosis. Results A total of 4% of patients with DWI diffusion limited or restricted, mild edge in 18% of the patients were non-uniform long T1 long T2 signals and equal T1 long T2 signals. 52% of the patients had homogeneous T1 and long T2 signal. The lesion edema and with multiple lesions accounted for 26%, 18%, cerebral hemisphere lesion in the largest proportion, 58% were higher than that of other lesions. 26 cases of enhanced scan findings in patients, 34% had semi annular enhancement, nodular enhancement, ring enhancement, irregular spot patchy enhancement were accounted for 8%, 4%, 6%. The above differences were statistically significant (P<0.05). In this group, 2 cases were misdiagnosed as glioma, accounting for 4%, which had a lower rate of misdiagnosis, and the diagnosis was satisfactory. Conclusion The diagnosis of inflammatory demyelinating pseudotumor of the central nervous system is of great significance in guiding the treatment of diseases. MRI has high reliability, and provides reliable evidence for effective treatment of diseases. It has significant application value and can be further applied.