Objective To analyze the MRI findings of glioblastoma in order to improve the diagnostic accuracy of glioblastoma. Methods MRI data of 50 cases of glioblastoma confirmed by surgery and pathology in our hospital from September 2012 to September 2017 were retrospectively analyzed. Results Of the 55 patients, 13 were frontal lobe, 4 of which were located in the frontal lobe alone, and the other 9 had different degrees of invasion of adjacent brain parenchyma. 26 cases were located in temporal lobe, 11 in temporal lobe alone, 14 in adjacent lateral ventricles, and 1 in the lateral ventricles. There were 7 cases in the parietal lobe and 9 cases in the occipital lobe. Glioblastoma has a relatively fast growth rate, and in general, the tumors are larger and irregular in shape. MRI classification can be divided into cystic degeneration, death, hemorrhagic and multiple types. The main manifestations were T1WI low signal and T2WI high signal mainly with uneven enhancement. Sometimes there was abnormal proliferation of vascular shadow in the tumor, and II-III degree edema and heavy occupying effect appeared around the tumor. Conclusion MRI is of high clinical value in the diagnosis of glioblastoma. The MRI findings of glioblastoma have certain characteristics and can be correctly diagnosed before operation.