Objective To observe and analyze the value of multi-slice spiral CT in the diagnosis of solitary pulmonary nodules. Methods The clinical data of 90 patients with solitary pulmonary nodules who had received treatment in the hospital between February 2016 and July 2017 were analyzed, and all the patients were diagnosed by multi-slice spiral CT, and the actual diagnostic value was observed. Results Among the 90 patients with solitary pulmonary nodules, patients with malignant pulmonary nodules accounted for 60.00%, benign pulmonary nodules accounted for 40.00%, with significant difference shown in air bronchogram and pleural indentation CT signs (P<0.05). The accuracy of multi slice spiral CT for solitary pulmonary nodule was 100.00%; net enhancement value and enhanced peak CT value in malignant pulmonary nodules were respectively (47.84±4.67) HU and (80.24±10.50) HU, both higher than those of benign pulmonary nodules, and the difference was statistically significant (P<0.05). Conclusion For patients with solitary pulmonary nodules, multi slice spiral CT is with higher diagnosis value and it is of significant value to be popularized in clinical application.