Objective To evaluate the clinical value of Dynamic contrast-enhanced MRI and diffusion-weight in endometrial carcinoma(stage Ia) and endometrial hyperplasia. Methods Routine magnetic resonance imaging (MRI), Dynamic contrast-enhanced MRI and DWI images of 20 cases of endometrial carcinoma (stage Ia) and 19 cases of endometrial hyperplasia confirmed by pathology in our hospital from January 2016 to February 2018 were collected. Endometrial carcinoma and endometrial hyperplasia were compared with surgical pathology. Results Twenty consecutive female patients with stage Ia endometrial cancer (18 endometrioid adenocarcinomas, 2 serous carcinomas), and We successfully obtained good image quality from all cases of imaging. The mean ADC value of stage Ia endometrial cancer (n=20)was (0.93±0.16)×10-3mm2 /s, which was significantly lower than that of uterine endometrial hyperplasia (n=19) was (1.36±0.31)×10-3mm2 /s,P=0.00<0.05]. The accuracy of stage Ia endometrial cancer were consistency with pathology(P<0.05), the accuracy of DWI was90%, which was better than DCE, and the accuracy of stage Ia was 85%. Conclusion DCE and DWI sequences can be used as a useful supplement to conventional MRI in differentiating endometrial carcinoma (stage Ia) and endometrial hyperplasia.