Objective To explore the effect of multi-slice spiral CT scan in patients with clinical colorectal cancer. Methods The clinical data of 240 patients with colon cancer confirmed by surgery and histopathology from February 2014 to August 2016 were retrospectively analyzed., all patients went on multi-slice spiral CT scan before surgery and 6 months after the surgery, compare the accuracy of multi-slice spiral CT scanning and record postoperative recurrence. Results The accuracy rate of T stage examination was 85.0%, the accuracy rate of N staging was 85.0%, the accuracy of M staging was 85.0%. Compared with the results of surgical tissue biopsy,χ2 =(21.43,18.24,6.66), P<0.05; postoperative multi-slice spiral CT scan, the use of multi-slice spiral CT preoperative examination of colon cancer, which T stage examination accuracy rate of 85.71%, N staging accuracy rate of 88.24 %, M stage check accuracy rate of 100.00%, compared with the results of surgical tissue biopsy,χ2 =(7.13,9.74,9.00), P<0.05. Conclusion The use of multi-slice spiral CT in the preoperative examination of colon cancer can help patients with clinical disease assessment, to guide the clinical treatment; postoperative through the use of multi-slice spiral CT monitoring can be helpful to determine the recurrence or metastasis of patients for patients with prognosis and clinical treatment program to provide reference.