Objective To study the value of dual energy pulmonary angiography (DECTPA) with dual-source CT (DSCT) in pulmonary embolism (PE). Methods Collected the clinical data of 26 patients suspected of PE in our hospital underwent DECTPA with DSCT. Assessed the value of dual energy pulmonary angiography (DECTPA) with dualsource CT (DSCT) in pulmonary embolism (PE). Results The 96.30%, 90.57% agreement between DEPI and CTPA were showed in the levels of lung and partial lung respectively. Complete filling defects of segmental and subsegmental pulmonary arteries mostly showed correspon dence perfusion defects in the CT perfusion map. However, when there were partial filling defects, most of them were partial perfusion defects. A few of them were normal in the CT perfusion map. With CTPA as a reference standard,in the level o f lung, the results show that compared with DEPI, the sensitivity was 96.30% (52/54), specificity of 100% (76/76). Conclusion There was moderate agreement between the judgement of CTPA and DEPI. The perfusion defects in the DEPI related to the degree and location of the filling defects in the CTP A. The combination of CTPA and DEPI will offer more information for diagnosis of the pulmonary embolism. It is worth promotion in the clinical.