Objective To study the CT findings of solitary pulmonary nodules and the application value of MSCT at early stage. Methods The CT findings of patients with the three kinds of solitary pulmonary nodules were retrospectively analyzed. All of the 74 patients underwent CT plain scan, enhanced scan and perfusion scan. The perfusion parameters of benign, inflammatory and malignant solitary pulmonary nodules were compared, including blood flow (BF), blood volume (BV), permeability surface (PS) and mean transit time (MTT). Results In terms of malignant nodules, among 37 cases of malignant nodules, there 31 cases with clear boundaries, accounting for 83.78%, 27 cases with lobulation, accounting for 72.97%, 22 cases with spiculation signs, accounting for59.46% and 17 cases with pleural indentation signs, accounting for45.95%. There were 10 cases of spiculate protuberance, 2 cases showing calcification and none satellite lesions. In terms of benign nodules, 16 cases of patients with benign nodules showed clear boundaries, 15 cases with calcification, accounting for 93.75%, with few light shadowwithin nodules, spiculate protuberanceand leaflets. There was only 1 case with pleural indentation signs and spiculation; In terms of inflammatory nodules, among the 21 cases of inflammatory nodules, there were 12 cases with satellite lesions, accounting for 57.14% and 11 cases with spiculate protuberance, accounting for 52.38%. Both of the above two were the main signs, with rare cavity, calcification and lobulation. BV, PS, BF, MTT value of four indicators, malignant patients with PS value is significantly higher than the inflammatory (P<0.05), There was no significant difference in other perfusion parameters (P>0.05). There were significant differences in BV, PS, BF and MTT between the two groups and the patients with benign nodules (P<0.05). Conclusion The CT findings of different pathological types ofsolitary pulmonary nodules are significantly different.There are significant differences in CT perfusion parameters between patients with inflammatory, malignant nodules and patients with benign nodules. However, PS value can be used as a reliable basis for the identification of inflammatory and malignant lesions.