Objective To investigate the MSCT manifestations of renal oncocytoma in order to improve the level of diagnosis and recognition. Methods The MSCT imaging, pathological features and clinical data of renal oncocytoma in 21 patients which had been proved by pathology were retrospectively reviewed. Results CT scans were performed on 21 lesions of renal oncocytoma, one of which accompanied with ipsilateral renal angiomyolipoma. Nine lesions located in the left kidney and 12 in the right kidney. The shape of all lesions appeared round or oval with clear boundaries, The diameters of these lesions ranged from 1.6cm to 13.5cm,with a mean of 6.7cm,Eight lesions were less than 4.0cm and 13 lesions were greater than or equal to 4.0cm in diameter. On CT plain scan,8 lesions showed iso-density or slightly hyper-density. A stellate central scar was detected in 14 lesions and punctate calcifications were found in 4 lesions. Dynamic enhancement scan showed spoke-wheel-like enhancement in all lesions in the corticomedullary phase. Fifteen lesions in cortical phase showed higher enhancement than that in parenchymal phase, while 6 lesions in parenchymal phase showed higher enhancement, Eight lesions had thick and tortuous vessels, twelve lesions appeared progressive enhancement from periphery to center,4 lesions presented segmental enhancement inversion and 12 lesions with central stellate scar had light enhancement, enhanced pseuedocapsule was observed around the margin in 13 lesions in the excretory phase. Conclusion MSCT multiphase scanning provides valuable features for the diagnosis of renal oncocytoma.