Head and Neck Imaging
Association between CT Features and Epidermal Growth Factor Receptor Mutation in Peripheral Non-small Cell Lung Cancer
Author：LI Chuan-jun, LUO Yan, WU Xiao-tao,et al.
affiliation：Department of Radiology, Shenzhen Pingshan District People's Hospital, Shenzhen 518020, Guangdong Province, China
PDFAbstract
Objective To investigate the association between CT characteristics of peripheral non-small cell lung cancer (NSCLC)and epidermal growth factor receptor(EGFR) gene mutation. Methods Clinical presentations and CT characteristics of 288 consecutive patients with pathological confirmed peripheral NSCLC were retrospectively reviewed. Logistic analysis was used to determine the association of clinical presentations and CT characteristicswith EGFR gene mutation. Results In the 288 patients, there were 148 patients with EGFR mutations (51.4%). Logistic analysis identified that gender (Odds Ratio:2.875[95% CI,1.455-5.682]) , tumor's texture (Odds Ratio: 0.535[95% CI，0.349- 0.821]) and pleural retraction (2.597[95% CI, 1.236-5.455]）were risk factors for EGFR gene mutation. Conclusion Gender, tumor's texture and pleural retraction were association with EGFR gene mutation in peripheral NSCLC. Combination CT characteristics and clinical presentation were useful for identified EGFR genotype of peripheral NSCLC.
【Keyword】Non-small Cell Lung Cancer; Epidermal Growth Factor Receptor; CT Characteristics
【Chart number】R734.2
【Document Identification Number】A
【DOI】10.3969/j.issn.1672-5131.2018.08.015
Chinese journal of CT and MRI
th16Volume， th 8 Issue
2018Year08Month
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