Objective To evaluate the effect of CT perfusion imaging (CTP) on hemodynamics in patients with moyamoya disease after cerebral revascularization. Methods 30 patients with moyamoya disease treated by cerebral vascular reconstruction in our hospital were selected as the subjects and the brain perfusion imaging was performed by multislice spiral CT. The CTP images of the patients were observed before and after operation, and the cerebral blood flow (rCBF) and relative cerebral blood volume were analyzed before and after the operation in the cerebral ischemia area. (rCBV), peak time (TTP), average passage time (MTT) and delay time (DLY). Results Of the 30 patients, 9 had cerebral hemorrhage symptoms, 21 cases had cerebral ischemia symptoms, 20 cases of single or multiple softening were found by imaging examination, 10 cases of hemorrhagic foci, 53 stenosis of different degree of internal carotid artery, including 18 cases of anterior cerebral artery stenosis, 21 cases of middle cerebral artery, 14cases of posterior cerebral artery, and abnormal collateral circulation. There were 7cases of bilateral cranial multi point drilling indirect blood flow reconstruction, and 23 cases were treated by direct blood flow reconstruction. 41 of abnormal perfusion areas were found by CTP examination in 30 patients, while the preoperative abnormal perfusion area was compared with that of bilateral normal areas, and rCBV and rCBF were significantly reduced, TTP, MTT and DLY were obviously prolonged. The comparison of rCBV and rCBF in abnormal perfusion area and bilateral relative normal area was significantly higher, and TTP, MTT and DLY were significantly shorter, but there was a significant difference between TTP, MTT and DLY (P<0.05). MTT and DLY were still prolonged. Conclusion CTP can provide cerebral blood flow information for the preoperation of moyamoya disease, which shows the stenosis, occlusion and abnormal condition of the patients. It can also show the changes of cerebral blood flow in the patients during the revascularization, which is of great significance for evaluating the dynamic changes of the patients with moyamoya disease after revascularization.