Objective To explore the mammography, ultrasonography and MRI examination in the clinical application value of early diagnosis of breast cancer patients. Methods 46 cases with breast cancer confirmed by surgery and pathology as the research object, underwent X-ray mammography, color Doppler ultrasound, MRI examination, to observe the performance of three methods of imaging, and check method to compare different mass, calcification, the internal structure of mass sensitivity of small lesions, compared the diagnostic rate. Results of three methods of the masses, no statistically significant differences in the sensitivity of two two small lesions (P>0.05); mammography and ultrasonography were higher than MRI on calcification of sensitivity, color Doppler ultrasound and MRI were higher than that of X-ray mammography is sensitive to the internal structure of the masses, the difference was statistically significant (P<0.05). X-ray mammography, ultrasound and MRI diagnosis coincidence rate was 89.1%,82.6%,78.3%, the combined diagnosis with rate was 97.8%. Conclusions mammography, color Doppler ultrasound, MRI examination method for early breast cancer showed that each has its advantages and disadvantages, diagnostic accuracy is limited, and take the joint inspection can maximize to avoid misdiagnosis and improve the diagnostic accuracy.