Objective To explore the clinical value of MR perfusion imaging technique for the early therapeutic effect with primary t chemotherapy for local advanced breast cancer and analyze the detection means as chemotherapy prognosis evaluation factor. Methods 33 cases of patients with LABC and randomly divide them into effective group and ineffective group, the data of TRR,GTV and MSILR before and after chemotherapy will be thoroughly examined.. Results The average volume of solid tumor in postoperative chemotherapy group is (2.88±1.02)cm3 ,the statistic is lower than that without chemotherapy and in ineffective group(P<0.05), the maximum signal loss rate was (14±11.17)%from effect group after treatment,which is significantly lower than the number from group before chemotherapy (41.51±3.5)% and ineffective group after chemotherapy (42.6±4.8)%.All of the data was statistically considered significant (P<0.05), The MSILR average value was positively correlated with tumor shrinking rate (r=0.313, P=0.44). Conclusion Magnetic resonance perfusion imaging technology has a certain clinical value for the early therapeutic effect monitoring tracking primary chemotherapy for local advanced breast cancer, but it still need further analysis and detection of big data support.