Head and Neck Imaging
Application of MRI with T1 Relaxation Time in the Rotating Frame in Liver Fibrosis in Rats*
Author：HU Gen-wen, QUAN Xian-yue, Queenie Chan, et al
affiliation：Department of Medical Image Center, Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen 518133, Guangdong Province,China
PDFAbstract
Objective To explore the value of T1 relaxation times in the rotating frame (T1ρ or T1rho) for liver fibrosis. Methods Liver fibrosis model rats (N=50) were produced by carbon tetrachloride (CCl4) injection. Five rats died during the experiment. Surviving model rats (N=45) and controls (N=15) were subjected to 3.0-T MRI and T1ρ values were determined. Liver fibrosis stage (F0–F4) was defined based on METAVIR scoring. Results T1ρ values associated positively (r=0.863,P<0.05) with severity of fibrosis stage. Conclusion T1ρ may be a new kind of noninvasive technique to show the changes of liver in pathology and histology during the progression of fibrosis.
【Keyword】T1 Relaxation Time in the Rotating Frame(T1ρ or T1rho); MRI; Liver Fibrosis
【Chart number】R445.2
【Document Identification Number】A
【DOI】 10.3969/j.issn.1672- 5131.2016.05.027
Chinese journal of CT and MRI
th14Volume， th 5 Issue
2016Year05Month
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