Objective To study the biochemical signs and CT image change in pancreatitis patients with integrated program. Methods Selected 80 cases with pancreatitis from October 2014 to October 2015 in the hospital, the patients were randomly divided into two groups according to the method, 40 cases in each group. The control group with conventional therapy, The experimental group with integrated treatment regimens, before and after treatment compared biochemical signs and CT affect change. Results The remission time, blood amylase returned to normal, urine amylase returned to normal, white blood cells return to normal time and length of hospital stay was significantly shorter than the control group (P<0.05), before treatment, two groups of patients,serum amylase, urine amylase blood cell biochemical signs indexes were no significant differences (P>0.05), after treatment, the experimental group serum amylase, urine amylase and biochemical signs of blood leukocyte index was significantly lower than the control group (P<0.05), two groups of patients former head of the pancreas, pancreatic body and tail of the pancreas scan various parts of the density and enhance the various parts of the density difference was not significant (P>0.05), experimental group patients with pancreatic head, pancreatic body and tail of the pancreas scan various parts of the density difference was not significant (P>0.05), the experimental group after treatment of pancreatic, pancreatic body and enhancing the site density was significantly higher (P<0.05), the experimental group after treatment enhanced pancreatic tail site density was significantly lower than the control group (P<0.05). Conclusion Integrated program used in the patients with pancreatitis can improve symptoms and biochemical indicators,it improve patient CT imaging situation and should be widely applied.