Objective Evaluation of tumor angiogenesis inhibition therapeutic effect by dynamic enhancement DCE-MRI imaging parameters. Methods 48 colon cancer nude mice transplanted tumors were randomly divided into two groups: the control group: 24 mice and the anticancer drug group: 24 mice. The control group of mice had the same amount of 0.9% sodium chloride solution injection and intraperitoneal injection of 5-FU 0.02ml/day, and routine MRI inspection and dynamic enhancement inspection respectively before treatment and 2、7 and 14 days after treatment. In each treatment period after treatment, 6 mice were sacrificed and given immunohistochemical staining, and correlation analysis of which and various dynamic enhancement inspection parameters was made. Results Among DCE-MRI parameters of the anticancer drug group, only Ktrans value and Kep value had their difference with that of the control group of statistical significance (P<0.05). And the contrast between the Ktrans value and Kep value of the 2 groups at the same time point and period was of statistical significance (P<0.05), indicating a good correlation in immunohistochemical analysis. The parameter value Ve was not of statistical significance. Conclusion The nude mice transplanted tumor model is of application value for animal tumor study, analysis of tumor angiogenesis or its closing after antitumor meditation with DCE-MRI imaging semi-quantitative and quantitative parameters.