刊期详情

Head and Neck Imaging订阅

Study of Intracerebral Loop in Patients with Schizophrenia Without Early Onset of Schizophrenia by Resting State Functional Magnetic Resonance Imaging*

Author：PEI Qi-li, ZHANG Hai-san, WANG Bi,et al.

affiliation：The Second Clinical College of Xinxiang Medical University, Xinxiang 453000, Henan Province, China

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Abstract

Objective To explore the abnormality of the inner loop in the patients with schizophrenia under the condition of resting state functional magnetic resonance image. Methods The subjects were included in 33 adolescents with untreated schizophrenia (group of patients) and 34 normal adolescents (control group), all of whom were subject to the resting-state functional magnetic resonance image (rs-fMRI).The data were analyzed by using amplitude of low-frequency fluctuation (ALFF) method, and the difference of resting brain function was analyzed after independent sample t test. Results The patients group increased in the left temporal gyrus, right hippocampus, right caudate nucleus, and thalamus ALFF, and decreased the ALFF value in the posterior cingulate cortex and the lower lobe, and the difference was statistically significant (P<0.005). Conclusion The pathogenesis of adolescent schizophrenia may be related to the functional abnormality of some brain regions in the striatum - thalamus - the default network loop.

【Keyword】Adolescent First-episode Untreated Schizophrenia; Functional Magnetic Resonance Imaging; Low-frequency Amplitude; Striatum-thalamic-default Network Loop

【Chart number】R749.3；R814.46

【Document Identification Number】A

【DOI】10.3969/j.issn.1672-5131.2018.07.021

Chinese journal of CT and MRI

th16Volume， th 7 Issue 2018Year07Month

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