Objective To investigate the clinical value of 64 slice CT first phase perfusion imaging in the diagnosis of lung cancer. Methods A total of 106 cases of patients with lung cancer treated in our hospital from 2014 January to 2015 February were included in the study, 63 cases were peripheral lung cancer, 43 cases were central type lung cancer. The precontrast and postcontrast attenuation on the hole tumor(ROIT), rich blood supply area(ROIR) and poor blood supply area(ROIP) were recorded, to calculate the perfusion volume and the peak height. Results The ROIT、ROIR、ROIP perfusion volume and the peak height of peripheral non small cell cancer were obviously higher than that of other tumors, while the parameters of central type non-small cell cancer were obviously lower than that of other tumors, the difference was statistically significant (P<0.05). The ROIT、ROIR、ROIP perfusion volume and the peak height of tumors which the diameter were more than 5cm were higher than those of the tumors which the diameter were less than 5cm, the difference was statistically significant (P<0.05); the mean peak height of small cell lung cancer on ROIP was (10.36±3.03)HU, lower than the non small cell cancer (15.08 ±8.11) HU, the difference was statistically significant (P<0.05). Conclusion The perfusion volume and peak height of the tumor may be associated with the size and location, and may had no correlation with the pathological types.