Objective To investigate the application value of MSCT (multi-slice spiral CT) in the evaluation of distal radius fractures classification, and compare with the X-ray. Methods 80 patients with distal radius fractures in our hospital were selected as the study object. All patients underwent X-ray radiography scanning of the positive side of the wrist joint. Then, MSCT was performed. Referring to AO standard, fracture classification was performed. The application value of X-ray and MSCT in the differentiation of different types of distal radius fractures was compared. Results Among the 80 cases of patients, 70 cases (87.50%) were diagnosed as fractures by X-ray and 10 cases were missed diagnosed among whom patients with type A, B and C fractures were 26 cases (37.14%), 24 cases (34.29%) and 20 cases (28.57%) respectively; 80 cases with fractures were diagnosed by MSCT and patients with type A, B and C fractures were 19 cases (23.75%), 31 cases (38.75%) and 30 cases (37.50%) respectively. The detection rate of MSCT (100.00%) was significantly higher than that of X-ray (87.50%) with statistically significant (χ2 =10.6667, P＜0.05). Conclusion MSCT is more detailed and accurate for differential diagnosis and classification of distal radius fractures. It is of relatively higher value in the diagnosis of more complex intra-articular fractures.