Objective To study the clinical value of color Doppler ultrasound (CDUS), CT angiography (CTA) and digital subtraction angiography (DSA) in the diagnosis of carotid stenosis lesions. Methods The imaging examination data of 60 patients suspected as carotid stenosis lesions who were admitted to our Department of Neurology from January 2016 to January 2018 were collected. The application value of CDUS, CTA and DSA in carotid stenosis lesions was explored. Results Among 60 patients, 42 cases were given CDUS and DSA, and 31 cases were given CTA and DSA, and 24 cases were given CDUS, CTA and DSA. The DSA results were used as the gold standard for the diagnosis of vascular stenosis, and the sensitivity, specificity and accuracy of CDUS in the diagnosis of carotid stenosis were 62.50%, 72.22% and 66.67% respectively, and the three indexes of CTA were 76.19%, 80.00% and 77.42% respectively, and the three indexes of CDUS+CTA were 80.00%, 75.00% and 79.17%respectively. It was found that the detection rate of unstable plaque was the highest by CDUS+CTA, followed by single CDUS and CTA, and the detection rate ofplaques was the lowest by DSA. Conclusion DSA is still the gold standard for the diagnosis of vascular stenosis, but CTA combined with CDUS is superior in longterm out-of-hospitalfollow-up of high-risk population and patients with cardiovascular diseases. CDUS combined with CTA also has good application value in screening vulnerable plaques.