Objective To evaluate the diagnostic value of dual-source computed tomography coronary angiography (DSCTA) in coronary artery stenosis of patients with coronary heart disease. Methods A total of 120 patients with coronary heart disease who admitted between September 2017 and September 2018 were selected for the study. All patients were given DSCTA, coronary angiography (CAG) and coronary intravascular ultrasound (IVUS). CAG was used as the gold standard to evaluate the efficacy and accuracy rate of stenosis of DSCTA in the diagnosis of coronary stenosis. IVUS examination was taken as the gold standard to evaluate the efficacy of DSCTA in diagnosing plaque properties. Results The sensitivity, specificity, accuracy rate, positive predictive value and negative predictive value of DSCTA in the diagnosis of coronary stenosis were 93.75%, 97.78%, 96.67, 94.17% and 97.62%. 1147 segments without coronary stenosis were accurately diagnosed by DSCTA and the accuracy rate was 97.62%, and 124 segments with mild coronary stenosis were diagnosed by DSCTA accurately and the accuracy rate was 84.93% (124/146), and 106 segments with moderate coronary stenosis were diagnosed and the accurate rate was 84.80% (106/125), and 163 segments with severe coronary stenosis were diagnosed and the accurate rate was 93.14% (163/175). A total of 394 atherosclerotic plaques were detected by IVUS, and 105 soft plaques were diagnosed DSCTA accurately and the accuracy rate was 82.68% (105/127), and 126 fibrous plaques were accurately diagnosed DSCTA and the accuracy rate was 89.36% (126/141), and 31 calcified plaques were diagnosed accurately by DSCTA and the accuracy rate was 81.58% (31/38), and 74 mixed plaques were diagnosed by DSCTA and the accuracy rate was 84.09% (74/88). Conclusion DSCTA is safe and non-invasive, and has high efficacy in diagnosing coronary stenosis, the degree of stenosis, and the diagnosis of atherosclerotic plaque in patients with coronary heart disease.