Objective To explore the value of 256-slice CT postoperative volume rendering in the diagnosis of coronary heart disease. Methods 63 cases of coronary heart disease patients treated in our hospital from June 2016 to November 2017 were selected. Those 63 cases patients were conducted CT examination and volume rendering treatment, their imaging data was collected. By the comparison with the results of coronary angiography examination, 256-slice CT volume rendering technique on the detection rate and diagnosis accuracy of coronary heart disease (CHD). Results The detection rate and diagnostic accuracy of volume reproduction technology for coronary heart disease were 98.41% (62/63) and 96.82% (61/63) respectively, among which the detection rate and diagnostic accuracy for mild stenosis were 94.73% and 89.47% respectively. Conclusion 256-slice CT postoperative volume rendering can effectively show the vascular stenosis in patients with coronary heart disease, and can accurately diagnose the vascular stenosis in patients with coronary heart disease, providing imaging data for the formulation of treatment plans in the later stage of clinical practice.