Objective To investigate the diagnostic value of CT angiography combined with 12-lead dynamic electrocardiogram (AECG) for the diagnosis of coronary heart disease. Methods A total of 92 patients with suspected coronary heart disease in our department from July 2015 to January 2018 were selected. All patients underwent multislice spiral CT and 12-lead AECG, confirmed by coronary angiography (CAG), taking CAG diagnosis results as the gold standard,the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of coronary heart disease by MSCT, 12-lead AECG and their combined diagnosis were calculated. Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of coronary heart disease by MSCT diagnosis were 86.79%, 87.18%, 86.95%, 90.19% and 82.93%, respectively, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of coronary heart disease by AECG diagnosis were 79.24%, 84.61%, 81.52%, 87.50%, and 75.00%, respectively. The combined diagnosis accuracy was significantly higher than that of MSCT and 12-lead AECG(P<0.05). Conclusion CT angiography combined with 12- lead dynamic electrocardiogram can improve the diagnostic accuracy of coronary heart disease and has potential to be promoted clinically.