Head and Neck Imaging
Application of 1 H-MRS in Assessing Prognosis of Primary Intracranial Diffuse Large B-cell Lymphoma
Author：FANG Meng-shi, XIAO Hui, FU Li-yuan, et al.
affiliation：Center of Medical Imaging,Fuzhou General Hospital, Bengbu Medical College, Fuzhou 350025, China
PDFAbstract
Objective To evaluate the application value of 1 H-MRS in assessing prognosis of primary intracranial diffuse large B-cell lymphoma (DLBCL) by comparing 1 H-MRS with pathology result. Methods MRI features, 1 H-MRS and pathology results of 11 intracranial DLBCL were retrospectively analyzed. Tumor location, appearance and signal were analyzed. Cho, Cr, NAA, NAA/Cr, Cho/Cr, Cho/NAA values of the tumor solid part and contralateral brain parenchyma were measured. Paired sample T test was used to compare the tumors and control brain parenchyma. Correlation of Cho and Ki-67 was analyzed with Spearman analysis. Results All 11 cases showed raised Cho, Cho/Cr and Cho/NAA, and decreased NAA, Cr and NAA/Cr. The statistical analysis demonstrated that all except Cr had statistical significance (P<0.05) between tumor solid region and compared normal brain. Spearman correlation analysis showed positive correlation between Cho and the expression level of Ki-67 (rs=0.627, P=0.039). Conclusion 1 HMRS has played an important role in preoperative diagnosis of intracranial DLBCL, it also could be used as an useful tool for assessing prognosis.
【Keyword】Diffuse Large B-cell Lymphoma; Magnetic Resonance Spectroscopy; Immunohistochemistry; Ki-67; Prognosis
【Chart number】R739.41
【Document Identification Number】A
【DOI】10.3969/j.issn.1672- 5131.2016.03.009
Chinese journal of CT and MRI
th14Volume， th 3 Issue
2016Year03Month
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