Objective To explore the diagnostic value of contrast-enhanced ultrasound combined with enhanced CT in the diagnosis of gallbladder space-occupying lesions. Methods 120 cases of patients admitted to our hospital from May 2017 to February 2018 for gallbladder space-occupying lesions were enrolled. All cases were confirmed by surgical pathology, and patients were given contrast-enhanced ultrasound and enhanced CT scan, and the results and pathological results were taken as gold standards to analyze the diagnostic accuracy of lesion types. Results The diagnostic accuracy of gallbladder polyps was 92.59%, and the diagnostic accuracy of gallbladder adenomyomatosis was 80.00% and the diagnostic accuracy of gallbladder cancer was 82.76% by contrast-enhanced ultrasound results and pathological results of gallbladder space-occupying lesions types. The diagnostic accuracy of gallbladder polyps was 88.89%, and the diagnostic accuracy of gallbladder adenomyomatosis was 70.00% and the diagnostic accuracy of gallbladder cancer was 89.66% by enhanced CT results and pathological results of gallbladder spaceoccupying lesions types. The diagnostic accuracy of gallbladder polyps was 97.53%, and the diagnostic accuracy of gallbladder adenomyomatosis was 90.00% and the diagnostic accuracy of gallbladder cancer was 96.55% by contrast-enhanced ultrasound and enhanced CT results and pathological results of gallbladder space-occupying lesions types. Contrastenhanced ultrasound combined with enhanced CT could significantly improve the accuracy of gallbladder-occupying tumor lesions, and the detection accuracy, specificity, sensitivity, positive predictive value and negative predictive value were higher than those of single contrast-enhanced ultrasound or single enhanced CT scan. The diagnostic accuracy of enhanced CT for gallbladder cancer classification was higher than that of contrast-enhanced ultrasound, and the combined detection results were basically consistent with enhanced CT scan results. Conclusion Contrast-enhanced ultrasound combined with enhanced CT has a positive effect on the diagnosis of gallbladder space-occupying lesions, and it can significantly improve the diagnostic accuracy.