Objective To discuss and study the application value of CT technique in the diagnosis of coronary artery disease in patients with H type hypertension. Methods 120 cases of patients with with essential hypertension who were eligible for inclusion criteria treated in our hospital were selected and treated with CT and coronary angiography, and detected the homocysteine (Hcy) levels. According to the Hcy levels, all patients were divided into H type hypertension group and simple hypertension group. The results were compared with CT and coronary angiography. The value of CT in the diagnosis of coronary artery lesions in patients with H type hypertension was analyzed. Results In the results of CT test and coronary angiography, there were no significant differences between the positive rates of coronary artery stenosis and calcification rates(P>0.05).The results of coronary angiography were noted as the "gold standard", and the positive predictive values of CT test in coronary artery stenosis and calcification were 100.00%, of which the sensitivities, accuracies and negative predictive values were higher.The the positive rate of coronary artery stenosis in the H type hypertension group (72.06%) was significantly higher than that in the simple hypertension group (50.00%) (P<0.05), and the calcification rate of the former(51.47%) was significantly higher than that of the latter (28.85%) (P<0.05). Conclusion The results of CT detection technique for the diagnosis of coronary artery disease are closed to those of coronary angiography,and the sensitivity, accuracy, positive and negative predictive values are relatively high, which has a high value of popularization and application.