Objective To analyze the CT characteristics of 26 patients with solid pseudo papillary tumors of pancreas and the application value of CT in the clinical diagnosis of the disease. Methods 26 patients with solid pseudo papillary tumors of pancreas confirmed by immunohistochemistry and pathology from January 2010 to October 2015 were treated as the research objects. Siemens Sensation 64 slice spiral CT machine was used for examination. The characteristics of multi-slice spiral CT imaging data of the patients were summarized. Results Among the 26 patients, the diseased regions of 9 patients were in the head of pancreas and 17 were in the tail of pancreas. The density of tumors was inhomogeneous and it was composed of cystic and solid components. The cystic component showed liquid low density shadow in plain scan, while the solid component showed low or equal density. Enhanced scan showed that cystic components were without enhancement, while solid components were with slight enhancement in the arterial phase and moderate inhomogeneous enhancement in venous phase and delayed phase, showing progressively centripetal enhancement. Most were with complete tumor capsule. Conclusion CT characteristics of patients with solid pseudo papillary tumors of pancreas include inhomogeneous density, no enhancement in cystic components after enhanced scan. There is mild enhancement in solid components in the arterial phase and moderate inhomogeneous enhancement in venous and delayed phase. It shouwed progressively centripetal enhancement, with complete capsule. It is relatively clearer, which is good for definite diagnosis of patients, with greater diagnostic value.