Objective To investigate the clinical value of multi-sequence magnetic resonance imaging(MRI) in acute cerebral hemorrhage. Methods A total of 49 cases of the acute phase of cerebral hemorrhage patients from our hospital from January 2016 to July 2016 were selected. All patients have performed multi-sequence MRI examination, and the patients' clinical data, imaging data were collected. Two associated chief physicians analyzed the characteristics according to the result of the MRI scan in the acute phase of cerebral hemorrhage. Results The hemorrhage demanstrated equal signal on T1WI in 31 patients (42.85%), with unclear boundary, slightly lower signal in 9 cases (18.36%), and circular low signal in 9 cases (18.36%). In T2WI sequences, most patients with high signal images showing in the hematoma region, there were also mixed signals. And the peripheral high-signal edema zone was seen in 26 cases (53.06%), which was relatively narrow. In one case (2.04%), the peripheral edema zone was significantly high, with the midline displacement. T2 FLAIR signal of the lesion was extremely low or showed low signal, while in 3 cases (6.12%), the signal on T2 FLAIR was high, medium and low signal. In the DWI sequence, the center of hematoma was extremely and showed low signal, and the surrounding moderate edema presented bright and high signal, with unclear boundary. In 12 cases (24.48%), the area of hematoma showed extremely low signal, and the peripheral areas that gave high signal were widened, and the area of local low signal area was implied. Conclusion Multi-sequence MRI examination can effectively display the location and image features of acute cerebral hemorrhage, with high imaging quality, and can improve the effective imaging data for clinical treatment.