Objective To analyze the clinical features and CT imaging findings of 85 patients with drug-induced liver injury (DILI)to provide references for clinical prevention, diagnosis and treatment. Methods A total of 85 patients with DILI diagnosed in the hospital from January 2010 to July 2018 were included in the study. Gender, age, medical history, medication history, clinical features, clinical classification, biochemical indicators of liver function and CT findings were analyzed retrospectively. Results The ratio of male to female in this study was 1:1.18, and most patients were between 41 and 60 years old, accounting for 73.75%. The most common clinical manifestations included poor appetite, fatigue, upper abdominal discomfort and loss of appetite. Among the patients with DILI, the proportion of three or more combinedmedication was the highest, followed by traditional Chinese medicines, antibiotics, antiviral drugs and non-steroidal anti-inflammatory drugs. The main clinical type of DILI was hepatocyte type, followed by cholestasis typeand the mixed type. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in hepatocytetype and mixed type were significantly higher than those in cholestasis type (P<0.05), but there was no significant difference in the level of glutamyl transferase (GGT) among the three types (P>0.05). CT showed that main types of DILI were diffuse liver injury and focal liver injury, accounting for 52.94% and 43.53%, respectively. Multifocal liver injury was rare, accounting for only 3.53%. The CT number of the them were 31~42Hu, 41~49Hu and 45~51Hu, respectively. CT showed decreased liver parenchyma density, multiple small patchy low-density lesions and multifocal low-density patchy shadow. Conclusion DILI occur in all ages, and the clinical manifestations are not specific. The drugs causing DILI are various. Therefore, clinical use of drugs should focus on medication safety when treating diseases. The main clinical type of DILI is hepatocyte injury, and the CT image is characteristic, which is of certain reference value for clinical diagnosis.