Objective To explore the application effects of ultrasound/computed tomography (CT) fusion imaging in the treatment of liver cancer difficult to display by conventional ultrasound. Methods The clinical data of 102 patients with focal hepatic lesions were visualized clearly by CT and not indicated by two-dimensional ultrasound were analyzed retrospectively. The pathological results of 102 patients were recorded, and the fusion conditions of the junior physicians (working years <3 years) and the senior physicians (working years >10 years) who used ultrasound/CT fusion imaging technique and the diagnostic effects of liver cancer were analyzed. Results Among 102 patients with focal hepatic lesions, there were 86 cases of primary liver cancer, 10 cases of hepatic hemangioma, 5 cases of hepatic vascular endothelial cell tumor and 1 case of liver nodular hyperplasia. The fusion success rates of the junior physicians and the senior physicians both were 100%, and there was no statistically significant difference (P>0.05). There was no significant difference in the diagnostic accuracy of ultrasound/CT fusion imaging between the junior physicians and the seniorphysicians (P>0.05). Conclusion Ultrasound/CT fusion imaging has high success rate and was not affected by human factors. And it can also assist in the diagnosis of primary liver cancer, and it has the advanteges of real-time, simple and stable.