Head and Neck Imaging

Diagnostic Value of Serum ACE2 Combined with Coronary CT Angiography for Coronary Heart Disease

Author:LIU Miao, NIU Suo-cheng, GUNA Wen-juan, et al.

affiliation:Department of Cardiology, the People's Hospital of Puyang City, Puyang 457000, Henan Province, China

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Abstract

Objective To observe the diagnostic value of serum angiotensin-converting enzyme 2 (ACE2) combined with coronary CT angiography (CTA) for coronary heart disease (CHD). Methods The clinical data of 116 patients with CHD were analyzed retrospectively. All patients were given coronary CTA, and serum ACE2 level was measured, and they were given coronary arteriography (CAG) within 3 months. CAG examination was used as the gold standard to compare the diagnostic efficacy of coronary CTA, ACE2 and combined diagnosis for CHD. Results The accuracy, sensitivity and specificity of serum ACE2 combined with coronary CTA in the diagnosis of CHD were 96.55%, 97.65% and 93.55% respectively, which were higher than those of coronary CTA alone (P>0.05). Kappa value of serum ACE2 combined with coronary CTA was greater than that of coronary CTA alone (0.912 vs 0.851). Conclusion Serum ACE2 combined with coronary CTA can improve the accuracy and sensitivity in the diagnosis of CHD compared with coronary CTA alone, and it has a high consistency with CAG.

【Keyword】Angiotensin-converting Enzyme 2; Coronary Angiography; Coronary Heart Disease; Diagnostic Value

【Chart number】R541

【Document Identification Number】A

【DOI】 10.3969/j.issn.1672- 5131.2019.03.009