Objective To evaluate the results of ultrasonography combined with MRI in diagnosis of breast cancer and its pathological classification. Methods A total of 81 cases of patients suspected of breast cancer were examined by color doppler ultrasound, MRI, or color doppler ultrasound combined with MRI. The diagnosis and pathological type were analyzed. Results The diagnostic rate of breast cancer for the color doppler ultrasound combined with MRI group were higher than the color doppler ultrasound group, and the omission diagnostic rate were lower than the color doppler ultrasound group(P ＜0.05), there were no significant difference on the diagnostic rate, omission diagnostic rate and misdiagnosis rate between the color doppler ultrasound combined with MRI group and MRI group(P＞0.05), the sensitivity, accuracy, negative predictive value of the color doppler ultrasound combined with MRI group were higher than the color doppler ultrasound group, and the accuracy were higher than the MRI group(P＜0.05), the image feature of color doppler ultrasound and MRI were had some connection with pathological type, and the coincidence rate of image feature and surgical pathology was high. Conclusion It has high accuracy in breast cancer by color doppler ultrasound with MRI. The image feature of color doppler ultrasound and MRI can provide good evidence for the diagnosis of the breast cancer.