Objective To investigate the CT image features of renal cell carcinoma associated with XP11.2 translocation/TFE gene fusion (Xp11.2/TFE RCC) and improve the accuracy of diagnosis. Methods CT data of seven cases Xp11.2/TFE RCC were analyzed retrospectively, the tumors' locations, sizes, shapes, densities, enhancement degrees, envelopes, perirenal tissue invasions and lymphatic metastasis, and other features, were observed respectively. Results Plain scans in 6 cases showed slightly high density and one case showed slightly hypodense in tumor, 3 cases showed extensive hemorrhage and necrosis in interior of the tumor and 5 cases showed calcification dots within it.In enhanced scans, all the cases showed moderate enhancement in renal cortex phase, the enhance degree of corticomedullary phase was the highest and excretory phase was lowest among cortex phase scans. Furthermore, the enhance degree of renal cortex phase and corticomedullary phase were both inferior to the renal cortex and exceeded in medulla kidney. The enhance degree of excretory phase was lower than medulla kidney. Conclusion Xp11.2/TFE RCC has certain CT characteristics which is conductive to identify subtypes of other renal cell carcinoma.