Objective To analyze the CT features and diagnostic value of nephroblastoma in children. Methods A total of 68 children with pathologically confirmed nephroblastoma who were admitted to our hospital between February 2014 and February 2016 were retrospectively analyzed. All cases underwent CT plain scan and enhanced scan. The CT features of nephroblastoma in children were analyzed, and the relationship between the CT features and surgical and pathological characteristics was analyzed. Results The average size of lesions in children was 4mm×73mm×98mm-146mm×142mm×117mm. The lesions were mainly distributed on one side and mostly occur in the upper pole. The lesions are mostly round or circular. Plain scan showed masses with uneven density. After the enhanced scan, the lesions showed mild to moderate uneven and delayed enhancement, and the residual pressed renal parenchyma showed crescent or annular enhancement. The accuracy of CT in the diagnosis of adjacent tissue invasion was 90.91%, and in the diagnosis of lymph node metastasis was 87.50%. Conclusion Nephroblastoma is more common in children under 5 years old. CT can accurately show the tumor size, shape, distribution, density, invasion and metastasis of nephroblastoma. The findings of CT are characteristic, which is of great importance to tumor staging,development of treatment plan and prediction of prognosis.