Objective To investigate the relationship between DWI and immunohistochemical indexes of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (CerbB-2) Nuclear antigen (Ki67) in lung cancer patients. Methods 102 patients with breast cancer from January 2012 to December 2016 were enrolled in this investigation. 102 cases of patients with breast cancer underwent breast dynamic enhanced MRI scan and diffusion weighted imaging (diffusion weigthed, imaging, DWI) sequence checking, obtain the feature of morphology, hemodynamics and ADC value detection in patients with postoperative pathological specimens, including histological grade, lymph node status and immune group chemical indicators (ER, PR, Ki-67, CerbB, -2), the analysis of dynamic enhanced MRI morphology and kinetics parameters, ADC value of the correlation between the index and breast cancer immunohistochemistry. Results (1) 80 cases of the 102 patients with breast cancer were invasive ductal carcinoma. Patients with irregular form were more common. Dynamic contrast enhanced tumor inhomogeneous enhancement in 51 cases, type III TIC in 69 cases. The mean SER value of patients was (123.54±43.52)%, mean maximum enhancement slope was (0.95±0.46)%. (2) the edge of the state, the maximum enhancement slope, TIC in each index correlation had no statistical significance (P>0.05). Tumor morphology and tumor size (P<0.001) were positively correlated. ER, PR (P=0.012, P=0.045) was negatively correlated with tumor morphology. Histological grading (P=0.011), ER (P=0.014), PR (P=0.009) and internal enhancement showed negative correlation; Signal enhancement rate was negatively correlated with tumor size (P=0.016) and lymph node status (P<0.001). Conclusion The dynamic and dynamic parameters of MRI and DWI scan are correlated with the immunohistochemistry of breast cancer. The prognosis of patients can be evaluated according to tumor morphology, internal enhancement and signal enhancement rate.