Objective To evaluate the MSCT characteristics of autoimmune pancreatitis. Methods Five autoimmune pancreatitis patients confirmed by pathology or clinical were retrospectively analyzed by the 64-slice spiral CT. Results Diffuse swelling of pancreas was found in three patients, just as sausage-shaped. Among them one case of the pancreatic head show obvious swelling, suspected neoplasm. Obvious pancreatic body and tail swelling in one patient. No significant swelling of the pancreas in one patient. Minimal peripancreatic stranding in three patients, peripancreatic fluid collection in two patients, focal enlargement with a capsule-like rim in one patient. Four patients showed homogeneous pancreatic density. One patient can be seen calification in the the pancreatic head . Pancreas showed mild homogeneous enhancement in all five patients. Distal common bile duct stricture can be seen in four patients as string-of-beads changes, with slight expansion of the pancreatic duct in two patients. One patient only showing pancreatic duct mild expansion. Two patients with extraparenchymal renal involment, showing perirenal stranding. One patient with renal pelvis involment, showing low density inflammatory mass and mild homogeneous enhancement. Conclusions MSCT can be used for the diagnosis of autoimmune pancreatitis, and also can be used to assess extrapancreatic lesions and pancreatic changes after treatment.