Obiective To investigate the differential value of dynamic contrast-enhanced MRI combined with diffusion-weighted imaging in diagnosing benign and malignant breast lesions presented as non-mass-like enhancement. Methods 105 cases diagnosed as breast cancers by pathologic examination underwent magnetic resonance prior to surgery. All cases performed non-mass-like enhancement in dynamic contrast-enhanced MR imaging. The morphological distribution, internal enhancement manner, the type of time-signal curve and ADC value were recorded,which were analyzed by chi-square test and Fisher's exact test,t test and ROC. Results Among the 105 cases of NMLE,malignant and benign lesions were 88 and 17,respectively.Segmental and clumped lesion were commonly observed in malignant cases(P<0.05),which were about 50.0%(44/88) and56.8% (50/88),respectively. Diffuse and stippled lesion were commonly observed in benign cases(P<0.05),which were about 29.4%(5/17) and 29.4%(5/17),respectively. The ADC value of benign and malignant lesion were (1.20±0.22)×10-3mm2 / s and(1.03±0.17)×10-3mm2 /s,respectively,the differences of which had statistical significance (P<0.05). With the threshold ADC value of 1.08×10-3mm2 /s for diagnosing benign and malignant lesion, the sensitivity and specificity were 63.6% and 76.5%, respectively.However, the differences of the type of time-signal curve between benign and malignant lesions had no statistical significance (P>0.05). Conclusions Benign and malignant property can be identified by the morphological distribution characteristics ,internal enhancement manner and ADC value of MRI in breast lesions presented as non-mass-like enhancement.