Objective To investigate the susceptibility weighted imaging (SWI) in Parkinson's disease (PD) and vascular vascular parkinsonism (VP) diagnosis, differential diagnosis of clinical value. Methods Collected in our hospital in June 2013-March 2015 30 cases were treated with Parkinson's disease (PD group) and 25 cases of patients with vascular parkinsonism (VP group), while 25 cases of healthy elderly will collect the same period (NC group) included in the control group. Three patients underwent magnetic resonance susceptibility weighted imaging compared three groups of patients in the substantia nigra pars compacta (SNc), substantia nigra pars reticulata band (SNr), red nucleus (RN), globus pallidus (GP), putamen (phase value PUT) and the caudate nucleus (CN) in. Results PD group in the substantia nigra pars compacta (SNc), globus pallidus (GP), putamen (PUT) phase was significantly lower than VP group (P<0.05),, red nucleus with two substantia nigra pars reticulata (SNr) (RN) and the caudate nucleus (CN) phase value was no significant difference (P>0.05), VP group phase value of each nuclei compared with the NC group had no significant difference (P>0.05). Conclusion Measured using susceptibility weighted imaging in patients with PD and VP with substantia nigra, globus pallidus, putamen phase values for both diagnosis and differential diagnosis play some reference value.