Objective To analyze the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings of patients with breast cancer before operation, and explore the relationship with expression levels of human vascular epidermal growth factor (VEGF) and human epidermal growth factor receptor -2 (Her-2). Methods DCE-MRI scan was performed in 52 patients with breast cancer before operation, and the imaging findings were analyzed. The expression of VEGF and Her-2 was detected, and the relationship with MRI was analyzed. Results MRI findings of breast cancer included edges in burr or irregular shape, fuzzy boundaries, irregular or lobulated shape, some lesions with necrosis, inhomogeneous or circular enhancement; Most of the tumors showed slightly low signal on T1W1, and inhomogeneous high signal on fat suppression T2W1. After injection of contrast agent, the enhanced scan showed obviously homogeneous or mottled inhomogeneous or circular enhancement; The positive expression rate of VEGF was 80%, and the positive expression rate of Her-2 was 76.67%; VEGF was significantly positively correlated with MRI burr (r=0.451, P=0.013) and early edge enhancement (r=0.843, P=0.001) in breast cancer, and Her-2 was significantly positively correlated with MRI internal necrotic lesions (r=0.451, P=0.034). Conclusion There is certain correlation between DCE-MRI findings of breast cancer and the expression of VEGF and Her-2, and MRI is of certain reference value in the treatment and prognosis of breast cancer.