Objective To investigate the diagnostic value of MSCT for gastrointestinal neuroendocrine neoplasms, and to increase the diagnostic rate. Methods In accordance with the 2010 WHO classification standard of tumors in the digestive system, clinical data and MSCT characteristics of 38 patients with gastrointestinal neuroendocrine neoplasms (GI-NENs) are retrospectively analyzed, which are pathologically confirmed by surgery and colonoscopy. Results Out of 38 patients there are 10 classified as G1, 4 are in G2, and rest are G3. Among 14 cases of G1 and G2 cancer, CT images without contrast of 12 cases showed mass-like or lobulated low-density mass with even density and smooth contour. And CT images of the other 2 cases showed irregular patching low-density lesion, in which there was small spot calcification. CT images with contrast of GI-NENs in the upper digestive tract showed significant contrast in arterial phase, and the density reduction occurred in the late phase. The lesions in the lower gastrointestinal tract had significant contrast in the venous phase or in balance phase. Conclusion The GI-NENs of this study had no specific clinical symptoms. MSCT imaging of G1 and G2 tumors had certain characteristics. The lesions had significant contrast, which appeared enhancement pattern as "fast-in and slow-out" in the upper gastrointestinal tract and appeared the contrast peak late in the lower digestive tract. MSCT imaging findings of G3 tumors were difficult to differentiate with other gastrointestinal cancers, however, it can be detected by the pathological features.