Objective To investigate and analyze the diagnostic sensitivity and accuracy of PET/CT 18F-FDG in the diagnosis of ovarian cancer recurrence and metastasis. Methods 95 cases of ovarian cancer patients treated in our hospital from June 2014 to June 2011, the patients were treated with PET/CT 18F-FDG and CT. The sensitivity and accuracy of PET/CT 18F-FDG in the diagnosis of recurrence and metastasis of ovarian cancer were analyzed. Results The sensitivity, specificity, negative predictive value and positive predictive value of the two methods were not significantly different (P>0.05). The accuracy of CT was 71.12%, and the accuracy of PET/CT was 84.45%, which was significantly higher than that of CT (χ2 =3.89, P<0.05). The sensitivity, specificity, negative predictive value and positive predictive value of PET/CT in the two groups were not significantly different (P>0.05), and had no statistical significance. The accuracy of AUC ROC and were 80.23 and 0.83, respectively, and the accuracy of AUC and ROC were 92.23 and 0.96, respectively, compared with those without recurrence group (χ2 =4.87, 5.64, P<0.05), with statistical significance. PET/CT 18F-FDG has a good effect on the diagnosis of small foci of peritoneal metastasis. Conclusion PET / CT imaging is more accurate than the simple CT examination to determine the recurrence and metastasis of ovarian cancer, and to provide help for clinical evaluation and treatment.