Objective To analyze clinical and CT imaging features to improve the recognition level. Methods Clinical and CT data of 8 patients with the intraosseous pneumatocyst were collected, including 7 male and 1 female, aged 21-60 years with mean age of (38.9±6.1) years were analyzed. The location, size, shape, density, margin, the involved bone and the adjacent structures were observed. Results CT showed a solitary gas density within the bone in 8 cases and some liquid density shadow in 2 of 8 cases. 2 cases were located in the femoral head and 2 cases in the vertebral body adjacent to costovertebral joints. Another 4 cases were located in the vertebral body adjacent to endplate, the scapular bone adjacent to the shoulder joint, the ilium adjacent to sacral sacroiliac joint and rib close to the costal cartilage, respectively. The maximum diameter of lesion were 2-13mm. The lesion was round (5 cases), oval (1 case), lobulated (1 case) or irregular (1 case) in shape. The margin of all lesions were clear. Of them, 1 case was accompanied by sclerotic rim, 1 case had cortical bone local thinning, 4 cases had cortical bone interrupt, and 2 cases had a small amount of gas in the adjacent structures at the same time. Conclusions Intraosseous pneumatocyst is generally considered to be secondary to acquired gas-containing bone lesions, usually close to the joint and intervertebral disc. The cause of gas formation is closely related to the vacuum phenomenon. CT can help make a definite diagnosis of the intraosseous pneumatocys using the appearance of the gas density within the bone,