Objective To analyze the clinical value of 64 slice CT in diagnosis and prognosis of craniocerebral injury. Methods A total of 200 patients with craniocerebral injury were analyzed retrospectively, all the patients accepted CT scan after the injury, and had CT review in 24 hours if the CT result was negative, and had CT review in 2 to 3 days if the CT result was negative again. Then summarized the characteristics of CT imaging, and divided them into the three types according to the characteristics of CT image scores, and analyzed the influence to the prognosis. Results There were various of manifestations, such as epidural hemorrhage, subdural hemorrhage, skull fracture, subarachnoid hemorrhage, etc. The number of deaths, severe disability, moderate disability had significance difference among the mild disability, moderate disability and severe disability, P＜0.05. A total of 198 cases of patients with positive CT result, the sensitivity and specificity were 100%, the sensitivity of the first CT scan was 69.5% (139/200), and the first CT review was 73.9% (51/69) , the second time CT review was 100% (18/18). Conclusion CT had obvious advantages in the diagnosis of craniocerebral injury because of the high sensitivity and specificity. And the CT results had close relationship with the prognosis, which could be the clinical guidance, and deserve to be the first choice for the craniocerebral injury patients.