Head and Neck Imaging

Dynamic Contrast-enhanced MR in Evaluation of Recurrence of Stage ⅡCervical Carcinoma*

Author:GUO Ji-min1 , ZHU Zhi-jun1 , ZHANG Bi-juan2 , et al.

affiliation:1 Department of Radiology Southern Medical University Affiliated Shenzhen Maternity and Child Care; 2 Reproductive Center Peking University Shenzhen Hospital; 3 Zhujiang Hospital, Southern Medical University

PDF

Abstract

Objective To judge the value and significance of stage Ⅱ cervical squamous cell carcinoma recurrence Ⅱ by using dynamic contrast-enhanced MR. Methods Patients with stage Ⅱ cervical squamous cell carcinoma 48 cases (including 12 cases of patients with recurrent cervical squamous cell carcinoma,36 cases of patients with no recurrence cervical squamous cell carcinoma) were obtained preoperative MRI, 4D-THRIVE dynamic contrast-enhanced MRI and postoperative. In Matlab platform region of interest STC and CTC were obtained nonlinear fitting microvascular permeability parameters Ktrans, Kep and Ve values, evaluate recurrence group and no recurrence group vascular permeability characteristics. And to value MRI in postoperative follow-up. Results There were differences between the recurrent cervical squamous cell carcinoma group and no recurrence for Ktrans and Kep(p<0.05),but for Ve(p>0.05). Area under the curve of Ktrans value is 0.90. When Ktrans≥0.73min-1, diagnosis of stage Ⅱ recurrent cervical squamous cell carcinoma in the sensitivity and specificity were 83.3% and 77.8%. Area under the curve of Kep value is 0.81. when Kep≥0.95 min-1, diagnosis of stage Ⅱ recurrent cervical squamous cell carcinoma in the sensitivity and specificity were 83.3% and 61.1%. While area under the curve of Ve is 0.5, which has no diagnostic value. Recurrent squamous cell carcinoma of the cervix with a specific MRI. Conclusion Preoperative dynamic contrastenhancement MRI to determine stage Ⅱ cervical squamous cell carcinoma has a high diagnostic efficacy of recurrence, postoperative MRI regular follow-up will help early detection of recurrent squamous cell carcinoma of the cervix.

【Keyword】4D-THRIVE, Dynamic Contrast-enhanced, Recurrent Cervical Squamous Cell Carcinoma, Microvascular Permeability

【Chart number】R737.33; R445.2

【Document Identification Number】A

【DOI】 10.3969/j.issn.1672- 5131.2015.06.01854