Objective To investigate the imaging findings and pathological features of pulmonary CT enhancement scan of pulmonary cryptococcosis (PC). Methods The clinical data of 54 patients who had PC confirmed by surgery and pathology and were admitted into the hospital during January 2009 to January 2015 were retrospectively analyzed. All patients underwent CT enhancement scan. The imaging findings were recorded and compared with pathological results. Results There were 30 cases of multiondule type, 18 cases of solitary nodule type and 6 cases of consolidation type detected by pulmonary CT. The lesion areas were located at the lower end of the pleura and were close to the wide base of pleura. The CT findings showed changes of inflammatory granuloma, thanatosis and non-calcification. Pathology indicated granuloma-like lesions, PAS(+) and CMS(+). Conclusion The specific CT findings of PC are lesion areas located in the lower end of the pleura and close to the wide base of pleura. The lesions manifest as changes of inflammatory granuloma, thanatosis and non-calcification. For patients with atypia lesions, the diagnostic accuracy can be improved, combined with pathological biopsy