Objective Through comparison and analysis of application values of MRI and CT to diagnose solid pseudopapillary tumor of the pancreas, this thesis aims to provide important reference value for clinical diagnosis of solid pseudopapillary tumor of the pancreas, so as to improve the detectable rate and the prognosis. Methods 14 patients with solid pseudopapillary tumor of the pancreas of our hospital are selected for MRI and CT scan and their scan results are taken for comparison with clinical pathological examinations. Results After comparison with the results of pathological examination for operations, it is found that MRI scan results of 4 patients are completely consistent with pathological examination results and the rate of correct diagnosis is 100.0%; the results of 10 patients' CT scan are completely consistent with the results of pathological examination for operations and the rate of correct diagnosis is 100.0%. The comparison of the correct rates of MRI and CT diagnoses has no statistical significance, P>0.05. The average time of MRI clinical diagnosis is (32.5±6.2)min, which is apparently longer than that of CT control group (17.6±3.4)min; this is of statistical meaning, P<0.05. Conclusion In comparison with MRI diagnosis, the correct rate of using CT to diagnose the solid pseudopapillary tumor of the pancreas is equivalent; besides, the time required for CT diagnosis is relatively shorter, this can enhance the clinical diagnosis efficiency and save certain time for patients' early selection of treatment program and early treatment.