Objective To study the value of Color Doppler ultrasound in the diagnosis of renal diffuse lesions. Methods 80 cases of diffuse lesions collected from 2013 June to 2014 June in my hospital underwent color Doppler ultrasonography of the kidney, including 42 cases of acute kidney disease patients (the acute group), another 38 cases of patients with chronic kidney disease (the chronic group), to explore the clinical value of color Doppler ultrasound in the diagnosis of renal diffuse lesions. Results There was statistically significant difference of BUN and Cr among the three groups(all P<0.05),acute group was significantly higher than chronic group and the control groups(all P<0.05),chronic group was significantly higher than that of control group (P<0.05);There was statistically significant difference of the length, width, thickness of kidney and renal cortical thickness among the three groups(all P<0.05),acute group was significantly higher than chronic group and the control groups(all P<0.05),chronic group was significantly lower than that of control group (P<0.05);There was statistically significant difference of Artery Vmax,RI and segment artery AT among the three groups(all P<0.05),arterial Vmax in acute group was significantly higher than chronic group and the control groups(all P<0.05),chronic group was significantly lower than that of control group (P<0.05);RI and segment artery AT in acute group was significantly lower than chronic group and the control groups(all P<0.05),chronic group was significantly higher than that of control group (P<0.05). Conclusion Color Doppler ultrasound technology can effectively assist clinical on renal chronic diffuse diagnosis, treatment and evaluation of prognosis of patients, and check method is safe and reliable, simple, non-invasive, is worth the clinical promotion and application